Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models

Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models

Abstract Background Mutations in the estrogen receptor alpha (ERα) 1 gene (ESR1) are frequently detected in ER+ metastatic breast cancer, and there is increasing evidence that these mutations confer endocrine resistance in breast cancer patients with advanced disease. However, their functional role...

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Bibliographic Details
Main Authors: Amir Bahreini, Zheqi Li, Peilu Wang, Kevin M. Levine, Nilgun Tasdemir, Lan Cao, Hazel M. Weir, Shannon L. Puhalla, Nancy E. Davidson, Andrew M. Stern, David Chu, Ben Ho Park, Adrian V. Lee, Steffi Oesterreich
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Breast Cancer Research
Subjects:
ESR1 mutations
Genome-edited cells
Metastatic breast cancer
Endocrine resistance
RNA-seq
Online Access:http://link.springer.com/article/10.1186/s13058-017-0851-4

Internet

http://link.springer.com/article/10.1186/s13058-017-0851-4

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