Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects.

Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects.

Pollution, including polycyclic aromatic hydrocarbons (PAH), may contribute to increased prevalence of asthma. PAH can bind to the Aryl hydrocarbon Receptor (AhR), a transcription factor involved in Th17/Th22 type polarization. These cells produce IL17A and IL-22, which allow neutrophil recruitment,...

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Bibliographic Details
Main Authors: Coline Plé, Ying Fan, Saliha Ait Yahia, Han Vorng, Laetitia Everaere, Cécile Chenivesse, Joanne Balsamelli, Imane Azzaoui, Patricia de Nadai, Benoit Wallaert, Gwendal Lazennec, Anne Tsicopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4393221?pdf=render

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http://europepmc.org/articles/PMC4393221?pdf=render

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