Enzymatic synthesis of 4-methoxycinnamoylglycerol Uv filter mediated by immobilized-lipase and nanoparticle formation on N-succinylchitosan

• Main Authors: Sindy Escobar, Claudia Bernal, Monica Mesa
• Format: Article
• Language: Spanish
• Published: Universidad de Ciencias Aplicadas y Ambientales 2020-12-01
• Series: Revista U.D.C.A Actualidad & Divulgación Científica
• Subjects: cinnamate derivates; uv radiation filter; nanoparticles; immobilized lipases; (fragments found in mesh browser)
• Online Access: https://revistas.udca.edu.co/index.php/ruadc/article/view/1631

The synthesis of 4-methoxycinnamoylglycerol takes advantage of the biodiesel subproduct for obtaining a hydrophilic UV cinnamate derivate filter, useful in sunscreen formulations. The objective here was to demonstrate that esterification of 4-methoxycinnamic acid and glycerol mediated by immobilized-lipase from Thermomyces lanuginosus is selective towards 4-methoxycinnamoylglycerol monoester UV filter, whose chemical characteristics favor the nanoparticles formation by ionotropic gelation on N-Succinyl chitosan. A cinnamic acid conversion ~34% in hexane is higher than in other reports, without the presence of other sub-products or degradation products. This eases the purification process by liquid-liquid extraction. The free glyceryl entities favour its incorporation on N-Succinyl chitosan nanoparticles with size around 185±77nm, which are promissory for sunblock products.