Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation
The PI3K/PTEN-mTOR pathway regulates a variety of neuronal functions, including cell proliferation, survival, growth and plasticity. Dysregulation of the pathway is implicated in the development of both genetic and acquired epilepsies. Indeed, several causal mutations have been identified in patient...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-03-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00018/full |