Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones

Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones

The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities compara...

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Bibliographic Details
Main Authors: Perihan A. Elzahhar, Rana A. Alaaeddine, Rasha Nassra, Azza Ismail, Hala F. Labib, Mohamed G. Temraz, Ahmed S. F. Belal, Ahmed F. El-Yazbi
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
pyrazolyl thiazolones
anti-inflammatory
cyclooxygenase-1/cyclooxygenase-2
15-lipoxygenase
macrophage apoptosis
Online Access:http://dx.doi.org/10.1080/14756366.2021.1887169

Internet

http://dx.doi.org/10.1080/14756366.2021.1887169

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