The Regulation of the Small Heat Shock Protein B8 in Misfolding Protein Diseases Causing Motoneuronal and Muscle Cell Death

The Regulation of the Small Heat Shock Protein B8 in Misfolding Protein Diseases Causing Motoneuronal and Muscle Cell Death

Misfolding protein diseases are a wide class of disorders in which the aberrantly folded protein aggregates accumulate in affected cells. In the brain and in the skeletal muscle, misfolded protein accumulation induces a variety of cell dysfunctions that frequently lead to cell death. In motoneuron d...

Full description

Bibliographic Details
Main Authors: Riccardo Cristofani, Paola Rusmini, Mariarita Galbiati, Maria Elena Cicardi, Veronica Ferrari, Barbara Tedesco, Elena Casarotto, Marta Chierichetti, Elio Messi, Margherita Piccolella, Serena Carra, Valeria Crippa, Angelo Poletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Neuroscience
Subjects:
motoneuron diseases
amyotrophic lateral sclerosis
spinal and bulbar muscular atrophy
proteasome
autophagy
chaperones
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00796/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00796/full

Similar Items