Mining for Oxysterols in <i>Cyp7b1<sup>−/−</sup></i> Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

Mining for Oxysterols in <i>Cyp7b1<sup>−/−</sup></i> Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7&#945;-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease. SPG5 is medically characterized by loss of motor neurons in the corticospinal tract. In an effort to...

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Bibliographic Details
Main Authors: Anna Meljon, Peter J. Crick, Eylan Yutuc, Joyce L. Yau, Jonathan R. Seckl, Spyridon Theofilopoulos, Ernest Arenas, Yuqin Wang, William J. Griffiths
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Biomolecules
Subjects:
cytochrome P450
CYP7B1
hereditary spastic paraplegia
SPG5
25-hydroxycholesterol
7α,25-dihydroxycholesterol
cholestenoic acid
cholesterol
liquid chromatography–mass spectrometry
multistage fragmentation
Online Access:https://www.mdpi.com/2218-273X/9/4/149

Internet

https://www.mdpi.com/2218-273X/9/4/149

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