Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture

Abstract The hematopoietic stem cell (HSC) niche has been extensively studied in bone marrow, yet a more systematic investigation into the microenvironment regulation of hematopoiesis in fetal liver is necessary. Here we investigate the spatial organization and transcriptional profile of individual...

Full description

Bibliographic Details
Main Authors: Yanfang Lu, Miao Liu, Jennifer Yang, Sherman M. Weissman, Xinghua Pan, Samuel G. Katz, Siyuan Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00266-1