Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect

Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect

In our effort to develop novel and powerful agents with anti-proliferative activity, two new series of 1H-benzo[f]chromene derivatives, 4a–h and 6a–h, were synthesised using heterocyclocondensation methodologies under microwave irradiation condition. The structures of the target compounds were estab...

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Bibliographic Details
Main Authors: Hany E. A. Ahmed, Mohammed A. A. El-Nassag, Ahmed H. Hassan, Rawda M. Okasha, Saleh Ihmaid, Ahmed M. Fouda, Tarek H. Afifi, Ateyatallah Aljuhani, Ahmed M. El-Agrody
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Microwave synthesis
1H-benzo[f]chromenes
antitumour activity
SAR study
Caspase 3/7
Online Access:http://dx.doi.org/10.1080/14756366.2018.1476503

Internet

http://dx.doi.org/10.1080/14756366.2018.1476503

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