Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups). Here, we show that HIV-1 CA can bind multiple Nups, and that both natural and manipulated variation in Nup levels impacts HIV-1 i...

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Bibliographic Details
Main Authors: Melissa Kane, Stephanie V Rebensburg, Matthew A Takata, Trinity M Zang, Masahiro Yamashita, Mamuka Kvaratskhelia, Paul D Bieniasz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
HIV
nuclear import
integration
nucleoporin
Online Access:https://elifesciences.org/articles/35738

Internet

https://elifesciences.org/articles/35738

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