The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice

The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice

Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have prov...

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Bibliographic Details
Main Authors: Rosa Estrada-Reyes, Marcela Valdés-Tovar, Daniel Arrieta-Baez, Ana María Dorantes-Barrón, Daniel Quero-Chávez, Héctor Solís-Chagoyán, Jesús Argueta, Margarita L. Dubocovich, Gloria Benítez-King
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin
zeitgeber time
antidepressant-like effect
behavioral despair
forced-swimming test
tail suspension test
Online Access:http://www.mdpi.com/1422-0067/19/8/2278

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http://www.mdpi.com/1422-0067/19/8/2278

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