TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter

TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter

TonEBP is a key transcriptional activator in macrophages with an M1 phenotype. High expression of TonEBP is associated with many inflammatory diseases. Heme oxygenase-1 (HO-1), a stress-inducible protein, is induced by various oxidative and inflammatory signals, and its expression is regarded as an...

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Bibliographic Details
Main Authors: Eun Jin Yoo, Hwan Hee Lee, Byeong Jin Ye, Jun Ho Lee, Chae Young Lee, Hyun Je Kang, Gyu Won Jeong, Hyun Park, Sun Woo Lim, Whaseon Lee-Kwon, Hyug Moo Kwon, Soo Youn Choi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
NFAT5
M1 macrophages
M2 macrophages
inflammation
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00850/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00850/full

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