Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (“shedding”) of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking o...

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Bibliographic Details
Main Authors: Miguel Cavadas, Ioanna Oikonomidi, Catarina J. Gaspar, Emma Burbridge, Marina Badenes, Inês Félix, Alfonso Bolado, Tianyi Hu, Andrea Bileck, Christopher Gerner, Pedro M. Domingos, Alex von Kriegsheim, Colin Adrain
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
ADAM metalloproteases
ADAM17/TACE
iRhom2
14-3-3
MAP kinases
TNF
EGFR
ectodomain shedding
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313797

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http://www.sciencedirect.com/science/article/pii/S2211124717313797

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