Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy

Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy

We have approached the role of cellular stress in neurodegenerative diseases caused by polyglutamine expansion (polyQ) in the context of Spinocerebellar ataxia type 7 (SCA7) that includes retinal degeneration. Using the R7E mouse, in which polyQ-ataxin-7 is specifically over-expressed in rod photore...

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Bibliographic Details
Main Authors: Karine Merienne, James Friedman, Masayuki Akimoto, Gretta Abou-Sleymane, Chantal Weber, Anand Swaroop, Yvon Trottier
Format: Article
Language:English
Published: Elsevier 2007-03-01
Series:Neurobiology of Disease
Subjects:
Polyglutamine expansion
Neuronal stress
JNK/c-Jun pathway
Retina
Nrl
Photoreceptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002920

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http://www.sciencedirect.com/science/article/pii/S0969996106002920

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