Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy
We have approached the role of cellular stress in neurodegenerative diseases caused by polyglutamine expansion (polyQ) in the context of Spinocerebellar ataxia type 7 (SCA7) that includes retinal degeneration. Using the R7E mouse, in which polyQ-ataxin-7 is specifically over-expressed in rod photore...
Main Authors: | Karine Merienne, James Friedman, Masayuki Akimoto, Gretta Abou-Sleymane, Chantal Weber, Anand Swaroop, Yvon Trottier |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2007-03-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996106002920 |
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