Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure

Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure

Daptomycin (DAP) is one of the last-resort treatments for heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. DAP resistance (DAP-R) is multifactorial and mainly related to cell-envelope modifications caused by single-nucleotid...

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Bibliographic Details
Main Authors: Viviana Cafiso, Stefano Stracquadanio, Flavia Lo Verde, Irene De Guidi, Alessandra Zega, Giuseppe Pigola, Stefania Stefani
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Microbiology
Subjects:
daptomycin-resistant methicillin-resistant Staphylococcus aureus
genomics
SNPome
virulome
resistome
RNA-seq
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01893/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01893/full

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