Immune Modulation Properties of Zoledronic Acid on TcRγδ T-Lymphocytes After TcRαβ/CD19-Depleted Haploidentical Stem Cell Transplantation: An analysis on 46 Pediatric Patients Affected by Acute Leukemia

Immune Modulation Properties of Zoledronic Acid on TcRγδ T-Lymphocytes After TcRαβ/CD19-Depleted Haploidentical Stem Cell Transplantation: An analysis on 46 Pediatric Patients Affected by Acute Leukemia

TcRαβ/CD19-cell depleted HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) represents a promising new platform for children affected by acute leukemia in need of an allograft and lacking a matched donor, disease recurrence being the main cause of treatment failure. The use of z...

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Bibliographic Details
Main Authors: Pietro Merli, Mattia Algeri, Federica Galaverna, Giuseppe Maria Milano, Valentina Bertaina, Simone Biagini, Elia Girolami, Giuseppe Palumbo, Matilde Sinibaldi, Marco Becilli, Giovanna Leone, Emilia Boccieri, Lavinia Grapulin, Stefania Gaspari, Irma Airoldi, Luisa Strocchio, Daria Pagliara, Franco Locatelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
TcRγδ+ lymphocytes
zoledronic acid
TcRαβ/CD19 cell depleted haploidentical stem cell transplantation
acute leukemia
children
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00699/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00699/full

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