Localization and regional distribution of p23/TMP21 in the brain

Localization and regional distribution of p23/TMP21 in the brain

Sequential processing of amyloid precursor protein by β- and γ-secretases generates Alzheimer's disease (AD)-associated β-amyloid peptides. Recently it was reported that the transmembrane protein p23/TMP21 associates with γ-secretase, and negatively regulates β-amyloid production. Despite the l...

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Bibliographic Details
Main Authors: Kulandaivelu S. Vetrivel, Anitha Kodam, Ping Gong, Ying Chen, Angèle T. Parent, Satyabrata Kar, Gopal Thinakaran
Format: Article
Language:English
Published: Elsevier 2008-10-01
Series:Neurobiology of Disease
Subjects:
γ-secretase
Presenilin
Alzheimer's disease
Kainic acid
COP I
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001290

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http://www.sciencedirect.com/science/article/pii/S0969996108001290

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