SHP2, SOCS3 and PIAS3 Expression Patterns in Medulloblastomas: Relevance to STAT3 Activation and Resveratrol-Suppressed STAT3 Signaling

SHP2, SOCS3 and PIAS3 Expression Patterns in Medulloblastomas: Relevance to STAT3 Activation and Resveratrol-Suppressed STAT3 Signaling

Background: Activated STAT3 signaling is critical for human medulloblastoma cells. SHP2, SOCS3 and PIAS3 are known as the negative regulators of STAT3 signaling, while their relevance to frequent STAT3 activation in medulloblastomas remains unknown. Methods: Tissue microarrays were constructed with...

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Bibliographic Details
Main Authors: Cong Li, Hong Li, Peng Zhang, Li-Jun Yu, Tian-Miao Huang, Xue Song, Qing-You Kong, Jian-Li Dong, Pei-Nan Li, Jia Liu
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Nutrients
Subjects:
medulloblastoma
STAT3 signaling
STAT3 negative regulators
PIAS3
resveratrol
Online Access:http://www.mdpi.com/2072-6643/9/1/3

Internet

http://www.mdpi.com/2072-6643/9/1/3

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