Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action

Ferroquine (FQ or SR97193) is a novel antimalarial drug candidate, currently in development at Sanofi-Aventis. In contrast to conventional drugs, FQ is the first organometallic drug: a ferrocenyl group covalently flanked by a 4-aminoquinoline and a basic alkylamine. FQ is able to overcome the CQ res...

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Bibliographic Details
Main Authors: Faustine Dubar, Jamal Khalife, Jacques Brocard, Christophe Biot, Daniel Dive
Format: Article
Language:English
Published: MDPI AG 2008-11-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/13/11/2900/