Protein Degradation and the Pathologic Basis of Phenylketonuria and Hereditary Tyrosinemia

Protein Degradation and the Pathologic Basis of Phenylketonuria and Hereditary Tyrosinemia

A delicate intracellular balance among protein synthesis, folding, and degradation is essential to maintaining protein homeostasis or proteostasis, and it is challenged by genetic and environmental factors. Molecular chaperones and the ubiquitin proteasome system (UPS) play a vital role in proteosta...

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Bibliographic Details
Main Authors: Neha Sarodaya, Bharathi Suresh, Kye-Seong Kim, Suresh Ramakrishna
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
deubiquitination
inhibitors
protein quality control
proteolysis
protein stabilization
Online Access:https://www.mdpi.com/1422-0067/21/14/4996

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https://www.mdpi.com/1422-0067/21/14/4996

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