Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics

Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics

Physical exercise may provide protection against the cognitive decline and neuropathology associated with Alzheimer's disease, although the mechanisms are not clear. In the present study, APP/PSEN1 double-transgenic and wild-type mice were allowed unlimited voluntary exercise for 7 months. Cons...

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Bibliographic Details
Main Authors: Shailaja Kishan Rao, Jordan M. Ross, Fiona E. Harrison, Alexandra Bernardo, Randall S. Reiserer, Ronald S. Reiserer, James A. Mobley, Michael P. McDonald
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Exercise
Amyloid
Memory
Behavior
Cognition
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611500090X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611500090X

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