SIK2 represses AKT/GSK3β/β‐catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases

SIK2 represses AKT/GSK3β/β‐catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases

Salt‐inducible kinase 2 (SIK2) is an important regulator in various intracellular signaling pathways related to apoptosis, tumorigenesis and metastasis. However, the involvement of SIK2 in gastric tumorigenesis and the functional linkage with gastric cancer (GC) progression remain to be defined. Her...

Full description

Bibliographic Details
Main Authors: Xiao‐man Dai, Yan‐hui Zhang, Xiao‐han Lin, Xiao‐xing Huang, Yi Zhang, Chao‐rong Xue, Wan‐nan Chen, Jian‐xin Ye, Xin‐jian Lin, Xu Lin
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Molecular Oncology
Subjects:
AKT/GSK3β/β‐catenin signaling
autophagy
gastric cancer
protein phosphatases
SIK2
Online Access:https://doi.org/10.1002/1878-0261.12838

Internet

https://doi.org/10.1002/1878-0261.12838

Similar Items