Barrier abnormalities and keratinocyte-derived cytokine cascade after cessation of long-term topical glucocorticosteroid on hairless mouse skin

Barrier abnormalities and keratinocyte-derived cytokine cascade after cessation of long-term topical glucocorticosteroid on hairless mouse skin

Background: Previous studies have shown that topical corticosteroid (TCS) use induces structural abnormalities of the stratum corneum (SC), resulting in permeability barrier disruption. It is well-known that epidermal barrier perturbation induces a cytokine cascade, leading to cutaneous inflammation...

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Bibliographic Details
Main Authors: Tzu-Kai Lin, Kai-Jhe Wei, Chin-Han Wu, Feng-Jie Lai, Cheng-Che E. Lan, Chung-Hsing Chang, Amy Chia-Ying Peng, Jui-Chen Tsai, Hamm-Ming Sheu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-06-01
Series:Dermatologica Sinica
Subjects:
cytokines
epidermal permeability barrier
topical corticosteroids
withdrawal dermatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S102781171500052X

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http://www.sciencedirect.com/science/article/pii/S102781171500052X

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