Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling.

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling.

Interferons (IFNs) are cytokines that are central to the host defence against viruses and other microorganisms. If not properly regulated, IFNs may contribute to the pathogenesis of inflammatory autoimmune, or infectious diseases. To identify genetic polymorphisms regulating the IFN system we perfor...

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Bibliographic Details
Main Authors: Christian Lundtoft, Pascal Pucholt, Juliana Imgenberg-Kreuz, Jonas Carlsson-Almlöf, Maija-Leena Eloranta, Ann-Christine Syvänen, Gunnel Nordmark, Johanna K Sandling, Ingrid Kockum, Tomas Olsson, Lars Rönnblom, Niklas Hagberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009199

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https://doi.org/10.1371/journal.pgen.1009199

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