The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo

The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo

Background: Radiotherapy has a high curative potential in localized prostate cancer, however, there are still patients with locally advanced tumours who face a considerable risk of recurrence. Radiosensitization using molecular targeted drugs could help to optimize treatment for this high-risk group...

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Bibliographic Details
Main Authors: Steffi Liebscher, Lydia Koi, Steffen Löck, Michael H. Muders, Mechthild Krause
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Nelfinavir
Prostate cancer
Irradiation
Radiosensitization
Growth delay
Local tumor control
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630816300477

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http://www.sciencedirect.com/science/article/pii/S2405630816300477

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