Autophagy Inhibition Contributes to ROS-Producing NLRP3-Dependent Inflammasome Activation and Cytokine Secretion in High Glucose-Induced Macrophages

Autophagy Inhibition Contributes to ROS-Producing NLRP3-Dependent Inflammasome Activation and Cytokine Secretion in High Glucose-Induced Macrophages

Background: Type 2 diabetes is a persistent inflammatory response that impairs the healing process. We hypothesized that stimulation with high glucose following a pro-inflammatory signal would lead to autophagy inhibition, reactive oxygen species (ROS) production and eventually to the activation of...

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Bibliographic Details
Main Authors: Jiezhi Dai, Xiaotian Zhang, Li Li, Hua  Chen, Yimin Chai
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Macrophages
NLRP3 inflammasome
IL-1β
Autophagy
ROS
Online Access:http://www.karger.com/Article/FullText/480367

Internet

http://www.karger.com/Article/FullText/480367

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