The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism

The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism

Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion (GSIS) by pancreatic beta cells, where fatty acid-derived metabolites, such as long chain fatty acyl-CoAs, a...

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Bibliographic Details
Main Authors: Tsutomu eTomita, Kiminori eHosoda, Junji eFujikura, Nobuya eInagaki, Kazuwa eNakao
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Endocrinology
Subjects:
insulin secretion
GPR40
pancreatic beta cells
FFAR1
LCFA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00152/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00152/full

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