PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly

PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly

Mutations in proline-rich transmembrane protein 2 (PRRT2) are associated with a range of paroxysmal neurological disorders. PRRT2 predominantly localizes to the pre-synaptic terminals and is believed to regulate neurotransmitter release. However, the mechanism of action is unclear. Here, we use reco...

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Bibliographic Details
Main Authors: Jeff Coleman, Ouardane Jouannot, Sathish K. Ramakrishnan, Maria N. Zanetti, Jing Wang, Vincenzo Salpietro, Henry Houlden, James E. Rothman, Shyam S. Krishnakumar
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
PRRT2
SNARE proteins
synaptic fusion
neurotransmitter release
paroxysmal dyskinesia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717318806

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http://www.sciencedirect.com/science/article/pii/S2211124717318806

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