Cellular cholesterol distribution influences proteolytic release of the LRP-1 ectodomain

Cellular cholesterol distribution influences proteolytic release of the LRP-1 ectodomain

Low-Density Lipoprotein Receptor-related Protein-1 (LRP-1) is a multifunctional matricellular receptor composed of a large ligand-binding subunit (515-kDa α-chain) associated with a short trans-membrane subunit (85-kDa β-chain). LRP-1, which exhibits both endocytosis and cell signaling properties, p...

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Bibliographic Details
Main Authors: Bassil eDEKKY, Amandine eWAHART, Hervé eSARTELET, Michael eFERE, Jean-François eANGIBOUST, Stéphane eDEDIEU, Olivier ePIOT, Jérôme eDEVY, Hervé eEMONARD
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Pharmacology
Subjects:
Cholesterol
shedding
Raman microspectroscopy
Ectodomain
LRP-1 (low-density lipoprotein receptor-related protein-1)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00025/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00025/full

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