Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.

Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.

OBJECTIVES: ACAT2 is the exclusive cholesterol-esterifying enzyme in hepatocytes and enterocytes. Hepatic ABCA1 transfers unesterified cholesterol (UC) to apoAI, thus generating HDL. By changing the hepatic UC pool available for ABCA1, ACAT2 may affect HDL metabolism. The aim of this study was to re...

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Bibliographic Details
Main Authors: Matteo Pedrelli, Padideh Davoodpour, Chiara Degirolamo, Monica Gomaraschi, Mark Graham, Alice Ossoli, Lilian Larsson, Laura Calabresi, Jan-Åke Gustafsson, Knut R Steffensen, Mats Eriksson, Paolo Parini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3973598?pdf=render

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http://europepmc.org/articles/PMC3973598?pdf=render

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