Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition.

Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition.

Highly structured RNA derived from viral genomes is a key cellular indicator of viral infection. In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, phosphorylates eukaryotic initiation factor 2α and attenuates viral protein transla...

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Bibliographic Details
Main Authors: Edis Dzananovic, Astha, Grzegorz Chojnowski, Soumya Deo, Evan P Booy, Pauline Padilla-Meier, Kevin McEleney, Janusz M Bujnicki, Trushar R Patel, Sean A McKenna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5650172?pdf=render

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http://europepmc.org/articles/PMC5650172?pdf=render

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