Vemurafenib Limits Influenza A Virus Propagation by Targeting Multiple Signaling Pathways

Vemurafenib Limits Influenza A Virus Propagation by Targeting Multiple Signaling Pathways

Influenza A viruses (IAV) can cause severe global pandemic outbreaks. The currently licensed antiviral drugs are not very effective and prone to viral resistance. Thus, novel effective and broadly active drugs are urgently needed. We have identified the cellular Raf/MEK/ERK signaling cascade as cruc...

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Bibliographic Details
Main Authors: Magdalena Holzberg, Yvonne Boergeling, Tobias Schräder, Stephan Ludwig, Christina Ehrhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Microbiology
Subjects:
Vemurafenib
Raf/MEK/ERK cascade
MAP kinases
influenza A virus
signal transduction pathways
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02426/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02426/full

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