Infection Temperature Affects the Phenotype and Function of Chimeric Antigen Receptor T Cells Produced via Lentiviral Technology

Infection Temperature Affects the Phenotype and Function of Chimeric Antigen Receptor T Cells Produced via Lentiviral Technology

Chimeric antigen receptor (CAR)-T cell therapy has become an important method for the treatment of hematological tumors. Lentiviruses are commonly used gene transfer vectors for preparing CAR-T cells, and the conditions for preparing CAR-T cells vary greatly. This study reported for the first time t...

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Bibliographic Details
Main Authors: Xin Jin, Wenyi Lu, Meng Zhang, Xia Xiong, Rui Sun, Yunxiong Wei, Xiaoyuan He, Mingfeng Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
Lentivirus
Infection temperature
chimeric antigen receptor (CAR)
naive T cells
immune checkpoints
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.638907/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.638907/full

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