Activation of transmembrane receptor tyrosine kinase DDR1-STAT3 cascade by extracellular matrix remodeling promotes liver metastatic colonization in uveal melanoma

Activation of transmembrane receptor tyrosine kinase DDR1-STAT3 cascade by extracellular matrix remodeling promotes liver metastatic colonization in uveal melanoma

Abstract Colonization is believed a rate-limiting step of metastasis cascade. However, its underlying mechanism is not well understood. Uveal melanoma (UM), which is featured with single organ liver metastasis, may provide a simplified model for realizing the complicated colonization process. Becaus...

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Bibliographic Details
Main Authors: Wei Dai, Shenglan Liu, Shubo Wang, Li Zhao, Xiao Yang, Jingfeng Zhou, Yun Wang, Jing Zhang, Ping Zhang, Ke Ding, Yangqiu Li, Jingxuan Pan
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00563-x

Internet

https://doi.org/10.1038/s41392-021-00563-x

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