Suppression of optineurin impairs the progression of hepatocellular carcinoma through regulating mitophagy

Suppression of optineurin impairs the progression of hepatocellular carcinoma through regulating mitophagy

Abstract Autophagy removes damaged organelles to inhibit malignant transformation during tumor initiation. Once a cancer matures, it uses the autophagic pathway as an energy source. Optineurin (OPTN) is an autophagy adaptor protein that recruits microtubule‐associated protein 1 light chain 3, an aut...

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Bibliographic Details
Main Authors: Shoichi Inokuchi, Tomoharu Yoshizumi, Takeo Toshima, Shinji Itoh, Kyohei Yugawa, Noboru Harada, Hiroyuki Mori, Takasuke Fukuhara, Yoshiharu Matsuura, Masaki Mori
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Cancer Medicine
Subjects:
adaptor protein
autophagy
beta‐oxidation
liver
mitochondria
Online Access:https://doi.org/10.1002/cam4.3519

Internet

https://doi.org/10.1002/cam4.3519

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