Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products

Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products

Abstract Background The recent concept of secretome-based tissue regeneration has profoundly altered the field of regenerative medicine and offers promising novel therapeutic options. In contrast to medicinal products with a single active substance, cell-derived secretomes comprise pleiotropic bioac...

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Bibliographic Details
Main Authors: Maria Laggner, Alfred Gugerell, Christiane Bachmann, Helmut Hofbauer, Vera Vorstandlechner, Marcus Seibold, Ghazaleh Gouya Lechner, Anja Peterbauer, Sibylle Madlener, Svitlana Demyanets, Dirk Sorgenfrey, Tobias Ostler, Michael Erb, Michael Mildner, Hendrik Jan Ankersmit
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Stem Cell Research & Therapy
Subjects:
Regenerative medicine
Cell-free secretomes
Paracrine factors
Secretome
Good manufacturing practice
Reproducibility
Online Access:https://doi.org/10.1186/s13287-019-1524-2

Internet

https://doi.org/10.1186/s13287-019-1524-2

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