Membrane cholesterol removal changes mechanical properties of cells and induces secretion of a specific pool of lysosomes.

Membrane cholesterol removal changes mechanical properties of cells and induces secretion of a specific pool of lysosomes.

In a previous study we had shown that membrane cholesterol removal induced unregulated lysosomal exocytosis events leading to the depletion of lysosomes located at cell periphery. However, the mechanism by which cholesterol triggered these exocytic events had not been uncovered. In this study we inv...

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Bibliographic Details
Main Authors: Barbara Hissa, Bruno Pontes, Paula Magda S Roma, Ana Paula Alves, Carolina D Rocha, Thalita M Valverde, Pedro Henrique N Aguiar, Fernando P Almeida, Allan J Guimarães, Cristina Guatimosim, Aristóbolo M Silva, Maria C Fernandes, Norma W Andrews, Nathan B Viana, Oscar N Mesquita, Ubirajara Agero, Luciana O Andrade
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3869752?pdf=render

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http://europepmc.org/articles/PMC3869752?pdf=render

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