The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1β by Human Cytomegalovirus through Inhibition of NF-kB Activity

The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1β by Human Cytomegalovirus through Inhibition of NF-kB Activity

Interleukin-1β (IL-1β) is a key effector of the inflammasome complex in response to pathogens and danger signals. Although it is well known that assembly of the inflammasome triggers proteolytic cleavage of the biologically inactive precursor pro-IL-1β into its mature secr...

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Bibliographic Details
Main Authors: Matteo Biolatti, Valentina Dell’Oste, Sara Scutera, Francesca Gugliesi, Gloria Griffante, Marco De Andrea, Tiziana Musso, Santo Landolfo
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Viruses
Subjects:
human cytomegalovirus (HCMV)
pp65
inflammasome
interleukin-1β (IL-1β)
caspase-8
Online Access:http://www.mdpi.com/1999-4915/10/10/567

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http://www.mdpi.com/1999-4915/10/10/567

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