Clonal Upregulation of Effector Cytotoxic T Lymphocytes in a Patient with Multiple Tyrosine Kinase Inhibitor-Refractory Chronic Myeloid Leukemia with Long-Term Survival

Clonal Upregulation of Effector Cytotoxic T Lymphocytes in a Patient with Multiple Tyrosine Kinase Inhibitor-Refractory Chronic Myeloid Leukemia with Long-Term Survival

We present the case of a patient with multiple tyrosine kinase inhibitor (TKI)-refractory chronic phase chronic myeloid leukemia (CP-CML) with a T315I mutation of abl1. Dasatinib, a second-generation TKI, was administered as the initial treatment but achieved neither a cytogenetic nor molecular resp...

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Bibliographic Details
Main Authors: Tatsuro Jo, Takahiro Sakai, Kaori Matsuzaka, Kazuhiro Noguchi, Shizuka Hayashi, Masatoshi Matsuo, Jun Taguchi
Format: Article
Language:English
Published: Karger Publishers 2021-03-01
Series:Case Reports in Oncology
Subjects:
chronic myeloid leukemia
cytotoxic t lymphocyte
tyrosine kinase inhibitor
t-cell receptor repertoire
Online Access:https://www.karger.com/Article/FullText/514631

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https://www.karger.com/Article/FullText/514631

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