IL-15 fosters age-driven regulatory T cell accrual in the face of declining IL-2 levels

IL-15 fosters age-driven regulatory T cell accrual in the face of declining IL-2 levels

We and others have shown that regulatory T cells (Treg) accumulate dramatically with age in both humans and mice. Such Treg accrual contributes to age-related immunosenescence as they reduce the response to tumors and parasite infection. While we reported earlier that aged Treg have decreased expr...

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Bibliographic Details
Main Authors: Jana eRaynor, Allyson eSholl, David R. Plas, Philippe eBouillet, Claire A Chougnet, David A Hildeman
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Immunology
Subjects:
Aging
IL-2
Bim
CD25
Treg
IL-15
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00161/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00161/full

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