Puromycin A, B and C, cryptic nucleosides identified from Streptomyces alboniger NRRL B-1832 by PPtase-based activation

Puromycin A, B and C, cryptic nucleosides identified from Streptomyces alboniger NRRL B-1832 by PPtase-based activation

Natural product discovery is pivot for drug development, however, this endeavor is often challenged by the wide inactivation or silence of natural products biosynthetic pathways. We recently developed a highly efficient approach to activate cryptic/silenced biosynthetic pathways through augmentation...

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Bibliographic Details
Main Authors: Xiaoli Yan, Benyin Zhang, Wenya Tian, Qi Dai, Xiaoqin Zheng, Ke Hu, Xinxin Liu, Zixin Deng, Xudong Qu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Puromycin
Phosphopantetheinyl transferase
Gene activation
Streptomyces alboniger
Genome mining
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X17300844

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http://www.sciencedirect.com/science/article/pii/S2405805X17300844

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