An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer.

Targeted therapies have been used to combat many tumor types; however, few have effectively improved the overall survival in women with epithelial ovarian cancer, begging for a better understanding of this deadly disease and identification of essential drivers of tumorigenesis that can be targeted e...

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Bibliographic Details
Main Authors: Geetika Sethi, Harsh B Pathak, Hong Zhang, Yan Zhou, Margret B Einarson, Vinod Vathipadiekal, Sumedha Gunewardena, Michael J Birrer, Andrew K Godwin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3467214?pdf=render