Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.

Bibliographic Details
Main Authors: Andrea Canal-Martín, Javier Sastre, María José Sánchez-Barrena, Angeles Canales, Sara Baldominos, Naiara Pascual, Loreto Martínez-González, Dolores Molero, Mª Encarnación Fernández-Valle, Elena Sáez, Patricia Blanco-Gabella, Elena Gómez-Rubio, Sonsoles Martín-Santamaría, Almudena Sáiz, Alicia Mansilla, F. Javier Cañada, Jesús Jiménez-Barbero, Ana Martínez, Ruth Pérez-Fernández
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10627-w

Internet

https://doi.org/10.1038/s41467-019-10627-w

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