Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies

Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies

In recent animal experiments with suspensions of radiolabeled TiO2 nanoparticles large and highly variable radioactivity fractions were retained in disposable plastic syringes. After unloading between 10% and up to 70% of the loaded dose were still present in the syringes. As a consequence the effec...

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Bibliographic Details
Main Authors: Uwe Holzwarth, Unai Cossío, Jordi Llop, Wolfgang G. Kreyling
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
nanoparticle retention in plastic syringes
disposable plastic syringes
dosage uncertainty
dosage reproducibility
in vivo studies
nanomedicine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01293/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01293/full

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