Heterologous expression of nattokinase from B. subtilis natto using Pichia pastoris GS115 and assessment of its thrombolytic activity

Abstract Background Nattokinase is a fibrinolytic enzyme that has huge market value as a nutritional supplement for health promotion. In order to increase nattokinase yields, fermentation conditions, strains, cultivation media, and feeding strategies have been optimized. Nattokinase has been express...

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Bibliographic Details
Main Authors: Yan Guangbo, Shu Min, Shen Wei, Ma Lixin, Zhai Chao, Wang Yaping, Huang Zunxi
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Biotechnology
Subjects:
Online Access:https://doi.org/10.1186/s12896-021-00708-4