BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells

BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells

Abstract Background Facioscapulohumeral dystrophy (FSHD) is a progressive muscle disease caused by mutations that lead to epigenetic derepression and inappropriate transcription of the double homeobox 4 (DUX4) gene in skeletal muscle. Drugs that enhance the repression of DUX4 and prevent its express...

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Bibliographic Details
Main Authors: Amy E. Campbell, Jonathan Oliva, Matthew P. Yates, Jun Wen Zhong, Sean C. Shadle, Lauren Snider, Nikita Singh, Shannon Tai, Yosuke Hiramuki, Rabi Tawil, Silvère M. van der Maarel, Stephen J. Tapscott, Francis M. Sverdrup
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Skeletal Muscle
Subjects:
Facioscapulohumeral muscular dystrophy
FSHD
DUX4
Bromodomain
Adrenergic
High-throughput screening
Online Access:http://link.springer.com/article/10.1186/s13395-017-0134-x

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http://link.springer.com/article/10.1186/s13395-017-0134-x

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