Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus

Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus

Calcineurin is a key protein phosphatase required for hyphal growth and virulence in Aspergillus fumigatus, making it an attractive antifungal target. However, currently available calcineurin inhibitors, FK506 and cyclosporine A, are immunosuppressive, limiting usage in the treatment of patients wit...

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Bibliographic Details
Main Authors: Praveen Rao Juvvadi, Yan eMa, Amber eRichards, Erik eSoderblom, Arthur eMoseley, Frederic eLamoth, William J Steinbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Microbiology
Subjects:
Aspergillus fumigatus
Calcineurin
Mutation
Phosphorylation
Calcineurin-binding protein (CbpA)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00175/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00175/full

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