Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score.

Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score.

Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and immunologic responses to infection and as a tool for vaccine development. As the frequency and intent for use in vaccine comparisons increases, st...

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Bibliographic Details
Main Authors: Chad K Porter, Amanda Lynen, Mark S Riddle, Kawsar Talaat, David Sack, Ramiro L Gutiérrez, Robin McKenzie, Barbara DeNearing, Brittany Feijoo, Robert W Kaminski, David N Taylor, Beth D Kirkpatrick, A Louis Bourgeois
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5874036?pdf=render

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http://europepmc.org/articles/PMC5874036?pdf=render

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