Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.

Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.

The FRAS1-related extracellular matrix 1 (FREM1) gene encodes an extracellular matrix protein that plays a critical role in the development of multiple organ systems. In humans, recessive mutations in FREM1 cause eye defects, congenital diaphragmatic hernia, renal anomalies and anorectal malformatio...

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Bibliographic Details
Main Authors: Tyler F Beck, Oleg A Shchelochkov, Zhiyin Yu, Bum Jun Kim, Andrés Hernández-García, Hitisha P Zaveri, Colin Bishop, Paul A Overbeek, David W Stockton, Monica J Justice, Daryl A Scott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3594180?pdf=render

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http://europepmc.org/articles/PMC3594180?pdf=render

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